| http://purl.uniprot.org/citations/10636891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10636891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10636891 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase C-theta (PKCtheta) is a Ca(2+)-independent PKC isoform that is selectively expressed in T lymphocytes (and muscle), and is thought to play an important role in T cell receptor-induced activation. To gain a better understanding of the function and regulation of PKCtheta, we have employed the yeast two-hybrid system to identify PKCtheta-interacting proteins. We report the isolation and characterization of a cDNA encoding a novel 335-amino acid (37. 5-kDa) PKCtheta-interacting protein termed PICOT (for PKC-interacting cousin of thioredoxin). PICOT is expressed in various tissues, including in T cells, where it colocalizes with PKCtheta. PICOT displays an N-terminal thioredoxin homology domain, which is required for the interaction with PKC. Comparison of the unique C-terminal region of PICOT with expressed sequence tag data bases revealed two tandem repeats of a novel domain that is highly conserved from plants to mammals. Transient overexpression of full-length PICOT (but not its N- or C-terminal fragments) in T cells inhibited the activation of c-Jun N-terminal kinase (but not extracellular signal-regulated kinase), and the transcription factors AP-1 or NF-kappaB. These findings suggest that PICOT and its evolutionary conserved homologues may interact with PKC-related kinases in multiple organisms and, second, that it plays a role in regulating the function of the thioredoxin system."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.3.1902"xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.3.1902"xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Villalba M."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Villalba M."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Bi K."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Bi K."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Witte S."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Witte S."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Isakov N."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/author | "Isakov N."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/pages | "1902-1909"xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/pages | "1902-1909"xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/title | "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain."xsd:string |
| http://purl.uniprot.org/citations/10636891 | http://purl.uniprot.org/core/title | "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain."xsd:string |