| http://purl.uniprot.org/citations/10640778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10640778 | http://www.w3.org/2000/01/rdf-schema#comment | "Constitutive expression of IFN-beta by HIV target cells may be an alternative or complementary therapeutic approach for the treatment of AIDS. We show that macrophages derived from CD34+ cells from umbilical cord blood can be efficiently transduced by a retroviral vector carrying the IFN-beta coding sequence. This results in resistance to infection by a macrophage-tropic HIV type 1, as shown by the drastic reduction in the HIV DNA copy number per cell and in p24 release. Moreover, IFN-beta transduction totally blocked secretion of proinflammatory cytokines after HIV infection. The constitutive IFN-beta production also resulted in an increased production of IL-12 and IFN-gamma Th1-type cytokines and of the beta-chemokines macrophage-inflammatory protein-1alpha, macrophage-inflammatory protein-1beta, and RANTES. RANTES was found to be involved in the HIV resistance observed, and this was correlated with a down-regulation of the CCR-5 HIV entry coreceptor. These results demonstrate the feasibility and the efficacy of such IFN-beta-mediated gene therapy. In addition to inhibiting HIV replication, IFN-beta transduction could have beneficial immune effects in HIV-infected patients by favoring cellular immune responses."xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.3.1582"xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/author | "Cremer I."xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/author | "De Maeyer E."xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/author | "Vieillard V."xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/pages | "1582-1587"xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/title | "Retrovirally mediated IFN-beta transduction of macrophages induces resistance to HIV, correlated with up-regulation of RANTES production and down-regulation of C-C chemokine receptor-5 expression."xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://purl.uniprot.org/core/volume | "164"xsd:string |
| http://purl.uniprot.org/citations/10640778 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10640778 |
| http://purl.uniprot.org/citations/10640778 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10640778 |
| http://purl.uniprot.org/uniprot/P01574#attribution-716F00A370E6902C22B2F7BA23431059 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10640778 |