| http://purl.uniprot.org/citations/10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10642508 | http://www.w3.org/2000/01/rdf-schema#comment | "The epithelial Na(+) channel (ENaC) regulates Na(+) absorption in epithelial tissues including the lung, colon and sweat gland, and in the distal nephrons of the kidney. When Na(+)-channel function is disrupted, salt and water homoeostasis is affected. The cytoplasmic regions of the Na(+)-channel subunits provide binding sites for other proteins to interact with and potentially regulate Na(+)-channel activity. Previously we showed that a proline-rich region of the alpha subunit of the Na(+) channel bound to a protein of 116 kDa from human lung cells. Here we report the identification of this protein as human Nedd4, a ubiquitin-protein ligase that binds to the Na(+)-channel subunits via its WW domains. Further, we show that WW domains 2, 3 and 4 of human Nedd4 bind to the alpha, beta and gamma Na(+)-channel subunits but not to a mutated beta subunit. In addition, when co-expressed in Xenopus oocytes, human Nedd4 down-regulates Na(+)-channel activity."xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3450503"xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/author | "Snyder P.M."xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/author | "McDonald F.J."xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/author | "Farr T.J."xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/author | "Coddington-Lawson S.J."xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/pages | "503-509"xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/title | "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits."xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/10642508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10642508 |
| http://purl.uniprot.org/citations/10642508 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10642508 |
| http://purl.uniprot.org/uniprot/P46934#attribution-014C46B476A6BCCBE331884F69E3B4B6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/P46934#attribution-CB2E57A81AC94ACE0A488BAA0E108830 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/P51170#attribution-C37EDC8A105BF35A89B12514E7ED71A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/P51168#attribution-C37EDC8A105BF35A89B12514E7ED71A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/P37088#attribution-C37EDC8A105BF35A89B12514E7ED71A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/#_Q99576-mappedCitation-10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/#_P51168-mappedCitation-10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/#_P51170-mappedCitation-10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10642508 |
| http://purl.uniprot.org/uniprot/#_P51172-mappedCitation-10642508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10642508 |