| http://purl.uniprot.org/citations/10642516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10642516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10642516 | http://www.w3.org/2000/01/rdf-schema#comment | "The disulphide-bond pattern of the heterodimeric disintegrin EMF-10, a potent and selective integrin alpha(5)beta(1) antagonist from Eristocophis macmahoni venom, was established by combination of amino-acid analysis, N-terminal sequencing and collision-induced dissociation by nanoelectrospray ionization quadrupole ion-trap MS of fragments isolated by reversed-phase HPLC after degradation of EMF-10 with oxalic acid. Each EMF-10 subunit contains four intrachain disulphide bonds. Two interchain cystine residues join the EMF-10 polypeptides. The intrachain linkages are conserved in monomeric disintegrins. A molecular model of EMF-10 was built using averaged NMR co-ordinates of flavoridin as a template. The active hairpin loops of the EMF-10 subunits occupy opposite locations at the ends of an elongated disulphide-bond ladder. In the EMF-10 model the N-terminal polypeptide of EMF-10B is close to the RGD-loop of the EMF-10A subunit, suggesting that the N-terminal region of the B-subunit could potentially influence the biological activity of the A-subunit."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3450573"xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3450573"xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Calvete J.J."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Calvete J.J."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Romero A."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Romero A."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Schrader M."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Schrader M."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Niewiarowski S."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Niewiarowski S."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Marcinkiewicz C."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Marcinkiewicz C."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Jurgens M."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/author | "Jurgens M."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/pages | "573-581"xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/pages | "573-581"xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/title | "Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin alpha5beta1 antagonist from Eristocophis macmahoni venom."xsd:string |
| http://purl.uniprot.org/citations/10642516 | http://purl.uniprot.org/core/title | "Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin alpha5beta1 antagonist from Eristocophis macmahoni venom."xsd:string |