| http://purl.uniprot.org/citations/10644829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10644829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10644829 | http://www.w3.org/2000/01/rdf-schema#comment | "This study aimed to assess the role of specific human papillomavirus type 16 (HPV-16) variants, in combination with p53 codon 72 polymorphism genotypes, in cervical carcinogenesis. An initial sequence analysis of HPV-16 long control, E6 and E7 regions of 53 well-defined cervical samples containing HPV-16 revealed that a T to G transition at nucleotide position 350 within the E6 open reading frame was the most common variation, the frequency of which seemed to decrease with increasing severity of the lesion. Therefore, a total of 246 cervical samples of residents of The Netherlands was specifically analysed for HPV-16 350G/T variants and/or p53 codon 72 genotypes. These comprised HPV-negative normal cervical scrapes (n=40), normal cervical scrapes containing HPV-16 (n=46), scrapes containing HPV-16 from women with abnormal cervical cytology participating in a non-intervention follow-up study without (n=38) and with (n=51) a histologically proven cervical intraepithelial neoplasia (CIN) III lesion at the end of the study, and cervical squamous cell carcinomas (n=71). Neither specific HPV-16 350G/T variants nor specific p53 genotypes were associated with a higher risk of developing CIN III or cervical cancer. However, HPV-16 350T variants were significantly over-represented in p53 Arg homozygous women with cervical cancer. This suggests that, in p53 Arg/Arg women, infection with HPV-16 350T variants confers a higher risk of cervical cancer."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.org/dc/terms/identifier | "doi:10.1099/0022-1317-81-2-317"xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "van Duin M."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "van Duin M."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Meijer C.J."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Meijer C.J."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Snijders P.J."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Snijders P.J."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Walboomers J.M."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Walboomers J.M."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Klaassen E."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Klaassen E."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Helmerhorst T.J."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Helmerhorst T.J."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Verheijen R.H."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Verheijen R.H."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Voorhorst F."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Voorhorst F."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Vossen M.T."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/author | "Vossen M.T."xsd:string |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10644829 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |