| http://purl.uniprot.org/citations/10648183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10648183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10648183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10648183 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis B virus (HBV) belongs to the genus Orthohepadnavirus of the family Hepadnaviridae. Having been found in various animals (duck, heron, woodchuck, ground squirrel, and primates), hepadnaviruses must have undergone a long history of evolution and may comprise more members than currently recognized. Chimpanzees may also have their own hepadnavirus, even if it might be very close to HBV. We analyzed HBV-like sequences from three chimpanzees (Pan troglodytes) that were most likely infected during their life in Africa in the wild. Two chimpanzees (Ch256 and Ch258) possessed a viral genome of 3182 nt in length with a 33-nt deletion in the preS1 region, which could not be classified into any of the six genotypes (A-F) of human HBV but was very homologous to a previously reported isolate from a London Zoo chimpanzee. Phylogenetically distinct from the HBV-like sequences from gibbons, orangutans, and a gorilla so far reported, the Ch256 and Ch258 isolates would represent an indigenous chimpanzee HBV (tentatively ChHBV). A third chimpanzee (Ch195) had a 3212-nt genome, classifiable into the genotype E of HBV. Because HBV-E has been found mostly in Africans, Ch195 may have been infected from a human source in Africa. However, an inverse scenario is also possible: a spread of HBV-E might have occurred from chimpanzees to humans a long time ago in Africa. Analysis of the arginine-rich C-terminal region of the core protein, which is well conserved among mammalian hepadnaviruses, indicated that HBV-E/F and nonhuman primate hepadnaviruses are much closer than HBV-A/B/C/D to the hepadnaviruses of woodchuck and ground squirrel. Our results support an "ex-nonhuman primate" hypothesis for the origin of HBV."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.1999.0102"xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.1999.0102"xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.1999.0102"xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Mishiro S."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Mishiro S."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Mishiro S."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Usuda S."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Usuda S."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Usuda S."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Brotman B."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Brotman B."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Brotman B."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Prince A.M."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Prince A.M."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/author | "Prince A.M."xsd:string |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10648183 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |