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| http://purl.uniprot.org/citations/10648242 | http://www.w3.org/2000/01/rdf-schema#comment | "During Drosophila oogenesis Gurken, associated with the oocyte nucleus, activates the Drosophila EGF receptor in the follicular epithelium. Gurken first specifies posterior follicle cells, which in turn signal back to the oocyte to induce the migration of the oocyte nucleus from a posterior to an anterior-dorsal position. Here, Gurken signals again to specify dorsal follicle cells, which give rise to dorsal chorion structures including the dorsal appendages. If Gurken signaling is delayed and starts after stage 6 of oogenesis the nucleus remains at the posterior pole of the oocyte. Eggs develop with a posterior ring of dorsal appendage material that is produced by main-body follicle cells expressing the gene Broad-Complex. They encircle terminal follicle cells expressing variable amounts of the TGFbeta homologue, decapentaplegic. By ectopically expressing decapentaplegic and clonal analysis with Mothers against dpp we show that Decapentaplegic signaling is required for Broad-Complex expression. Thus, the specification and positioning of dorsal appendages along the anterior-posterior axis depends on the intersection of both Gurken and Decapentaplegic signaling. This intersection also induces rhomboid expression and thereby initiates the positive feedback loop of EGF receptor activation, which positions the dorsal appendages along the dorsal-ventral egg axis."xsd:string |
| http://purl.uniprot.org/citations/10648242 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.127.4.841"xsd:string |
| http://purl.uniprot.org/citations/10648242 | http://purl.uniprot.org/core/author | "Roth S."xsd:string |
| http://purl.uniprot.org/citations/10648242 | http://purl.uniprot.org/core/author | "Peri F."xsd:string |
| http://purl.uniprot.org/citations/10648242 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10648242 | http://purl.uniprot.org/core/name | "Development"xsd:string |
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| http://purl.uniprot.org/citations/10648242 | http://purl.uniprot.org/core/title | "Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg."xsd:string |
| http://purl.uniprot.org/citations/10648242 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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