| http://purl.uniprot.org/citations/10648423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10648423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10648423 | http://www.w3.org/2000/01/rdf-schema#comment | "The mixed lineage leukemia (MLL) gene located at chromosome band 11q23 is frequently rearranged in patients with therapy-related acute monocytic leukemia who received topoisomerase II inhibitors. We have identified a novel fusion partner of MLL (FAB M5b) in a patient who developed t-AML 9 years after treatment for acute lymphoblastic leukemia (ALL). The leukemic cells had a sole karyotypic abnormality of t(3;11) (p21;q23). Screening of a genomic DNA library, prepared from leukemic cell DNA, identified rearranged clones composed of MLL and a novel gene on chromosome 3p21 (AF3p21). The AF3p21 gene encodes a protein of 722 amino acids, which contains an Src homology 3 (SH3) domain, a proline-rich domain, and a bipartite nuclear localizing signal (NLS). RNA analysis demonstrated that exon 6 of the MLL gene fused to exon 2 of the AF3p21 gene. The resulting chimeric protein consists of AT-hooks, methyltransferase, and transcription repressor domains of MLL in addition to the AF3p21 proline-rich domain and NLS but not the AF3p21 SH3 domain."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Nakamura H."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Sano K."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Sano K."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Hayakawa A."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Hayakawa A."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Piao J.-H."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Piao J.-H."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Kosaka Y."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/author | "Kosaka Y."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/pages | "1066-1068"xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/pages | "1066-1068"xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/title | "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/title | "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23)."xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/10648423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10648423 |
| http://purl.uniprot.org/citations/10648423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10648423 |