| http://purl.uniprot.org/citations/10652257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10652257 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor-mediated signalling was studied in porcine aortic endothelial cells expressing either wild-type fibroblast growth factor receptor-1 or a mutant receptor (Y766F) unable to bind phospholipase C-(&ggr;). Stimulation of cells expressing the wild-type receptor resulted in activation of phospholipases C, D and A(2) and increased phosphoinositide 3-kinase activity. Stimulation of the wild-type receptor also resulted in stress fibre formation and a cellular shape change. Cells expressing the Y766F mutant receptor failed to stimulate phospholipase C, D and A(2) as well as phosphoinositide 3-kinase. Furthermore, no stress fibre formation or shape change was observed. Both the wild-type and Y766F receptor mutant activated MAP kinase and elicited proliferative responses in the porcine aortic endothelial cells. Thus, fibroblast growth factor receptor-1 mediated activation of phospholipases C, D and A(2) and phosphoinositide 3-kinase was dependent on tyrosine 766. Furthermore, whilst tyrosine 766 was not required for a proliferative response, it was required for fibroblast growth factor receptor-1 mediated cytoskeletal reorganisation."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.113.4.643"xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/author | "Wakelam M.J."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/author | "Roberts S."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/author | "Claesson-Welsh L."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/author | "Landgren E."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/author | "Cross M.J."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/author | "Hodgkin M.N."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/pages | "643-651"xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/title | "Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/10652257 | http://purl.uniprot.org/core/volume | "113"xsd:string |
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