| http://purl.uniprot.org/citations/10652342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10652342 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin D2 is the only D-type cyclin expressed in mature mouse B-lymphocytes, and its expression is associated with retinoblastoma protein (pRB) and pRB-related protein phosphorylation and induction of E2F activity, as B-cells enter the cell cycle following stimulation via surface IgM and/or CD40. Cyclin D-dependent kinase activity is required for cell proliferation, yet cyclin D2(-/-) mice have normal levels of mature B-lymphocytes. Here we show that B-lymphocytes from cyclin D2(-/-) mice can proliferate in response to anti-IgM and anti-CD40, but the time taken to enter S-phase is longer than for the corresponding cyclin D2(+/+) cells. This is due to the compensatory induction of cyclin D3, but not cyclin D1, which causes pRb phosphorylation on CDK4-specific sites. This is the first demonstration that loss of a D-type cyclin causes specific expression and functional compensation by another member of the family in vivo and provides a rationale for the presence of mature B-lymphocytes in cyclin D2(-/-) mice."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.5.3479"xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/author | "Thomas N.S."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/author | "Lam E.W."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/author | "Sicinski P."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/author | "Klaus G.G."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/author | "Banerji L."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/author | "Glassford J."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/pages | "3479-3484"xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/title | "Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40."xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10652342 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10652342 |
| http://purl.uniprot.org/citations/10652342 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10652342 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU51-mappedCitation-10652342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/#_P30280-mappedCitation-10652342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/#_Q4FK45-mappedCitation-10652342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/#_Q9D8L9-mappedCitation-10652342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/Q9D8L9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/A0A0J9YU51 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/P30280 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10652342 |
| http://purl.uniprot.org/uniprot/Q4FK45 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10652342 |