| http://purl.uniprot.org/citations/10655211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10655211 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent evidence suggests a role for the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (pol II) in pre-mRNA processing. The yeast NRD1 gene encodes an essential RNA-binding protein that shares homology with mammalian CTD-binding proteins and is thought to regulate mRNA abundance by binding to a specific cis-acting element. The present work demonstrates genetic and physical interactions among Nrd1p, the pol II CTD, Nab3p, and the CTD kinase CTDK-I. Previous studies have shown that Nrd1p associates with the CTD of pol II in yeast two-hybrid assays via its CTD-interaction domain (CID). We show that nrd1 temperature-sensitive alleles are synthetically lethal with truncation of the CTD to 9 or 10 repeats. Nab3p, a yeast hnRNP, is a high-copy suppressor of some nrd1 temperature-sensitive alleles, interacts with Nrd1p in a yeast two-hybrid assay, and coimmunoprecipitates with Nrd1p. Temperature-sensitive alleles of NAB3 are suppressed by deletion of CTK1, a kinase that has been shown to phosphorylate the CTD and increase elongation efficiency in vitro. This set of genetic and physical interactions suggests a role for yeast RNA-binding proteins in transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/154.2.557"xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Wilson S.M."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Corden J.L."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Conrad N.K."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Patturajan M."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Swanson M.S."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Brow D.A."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/author | "Steinmetz E.J."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/pages | "557-571"xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/title | "A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II."xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/10655211 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10655211 |
| http://purl.uniprot.org/citations/10655211 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10655211 |
| http://purl.uniprot.org/uniprot/P53617#attribution-0D0246060AF78BA271E1FD3CC1577053 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10655211 |
| http://purl.uniprot.org/uniprot/P38996#attribution-0D0246060AF78BA271E1FD3CC1577053 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10655211 |
| http://purl.uniprot.org/uniprot/#_P38996-mappedCitation-10655211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10655211 |
| http://purl.uniprot.org/uniprot/#_P53617-mappedCitation-10655211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10655211 |
| http://purl.uniprot.org/uniprot/P53617 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10655211 |
| http://purl.uniprot.org/uniprot/P38996 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10655211 |