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http://purl.uniprot.org/citations/10656688http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10656688http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10656688http://www.w3.org/2000/01/rdf-schema#comment"We recently isolated a cDNA for hpttg, the human homolog of rat pituitary tumor transforming gene. Now we have analysed the expression of hpttg as a function of cell proliferation. hPTTG protein level is up-regulated in rapidly proliferating cells, is down-regulated in response to serum starvation or cell confluence, and is regulated in a cell cycle-dependent manner, peaking in mitosis. In addition, we show that hPTTG is phosphorylated during mitosis. Immunodepletion and in vitro phosphorylation experiments, together with the use of a specific inhibitor, indicate that Cdc2 is the kinase that phosphorylates hPTTG. These results suggest that hpttg is induced by, and may have a role in, regulatory pathways involved in the control of cell proliferation."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.org/dc/terms/identifier"doi:10.1038/sj.onc.1203320"xsd:string
http://purl.uniprot.org/citations/10656688http://purl.org/dc/terms/identifier"doi:10.1038/sj.onc.1203320"xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Dominguez A."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Dominguez A."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Pintor-Toro J.A."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Pintor-Toro J.A."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Romero F."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Romero F."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Luna R."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Luna R."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Ramos-Morales F."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Ramos-Morales F."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Multon M.-C."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Multon M.-C."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Tortolero M."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/author"Tortolero M."xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/name"Oncogene"xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/name"Oncogene"xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/pages"403-409"xsd:string
http://purl.uniprot.org/citations/10656688http://purl.uniprot.org/core/pages"403-409"xsd:string