| http://purl.uniprot.org/citations/10656792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10656792 | http://www.w3.org/2000/01/rdf-schema#comment | "A crucial event in DNA replication is the polymerase switch from the synthesis of a short RNA/DNA primer by DNA polymerase alpha/primase to the pro?cessive elongation by DNA polymerase delta. In order to shed light on the role of replication factor C (RF-C) in this process, the effects of RF-C on DNA polymerase alpha were investigated. We show that RF-C stalls DNA polymerase alpha after synthesis of approximately 30 nucleotides, while not inhibiting the polymerase activity per se. This suggested that RF-C and the length of the primer may be two important factors contributing to the polymerase switch. Furthermore the DNA binding properties of RF-C were tested. Band shift experiments indicated that RF-C has a preference for 5' recessed ends and double-stranded DNA over 3' ends. Finally PCNA can be loaded onto a DNA template carrying a RNA primer, suggesting that a DNA moiety is not necessarily required for the loading of the clamp. Thus we propose a model where RF-C, upon binding to the RNA/DNA primer, influences primer synthesis and sets the conditions for a polymerase switch after recruiting PCNA to DNA."xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1999.3395"xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/author | "Ferrari E."xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/author | "Hubscher U."xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/author | "Mossi R."xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/author | "Keller R.C."xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/pages | "803-814"xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/title | "DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length."xsd:string |
| http://purl.uniprot.org/citations/10656792 | http://purl.uniprot.org/core/volume | "295"xsd:string |
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