| http://purl.uniprot.org/citations/10660609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10660609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10660609 | http://www.w3.org/2000/01/rdf-schema#comment | "The amino-terminal enhancer of split (AES) encodes a 197-amino acid protein that is homologous to the NH(2)-terminal domain of the Drosophila Groucho protein but lacks COOH-terminal WD40 repeats. Although the Drosophila Groucho protein and its mammalian homologs, transducin-like enhancer of split proteins, are known to act as non-DNA binding corepressors, the role of the AES protein remains unclarified. Using the yeast two-hybrid system, we have identified the protein-protein interaction between AES and the p65 (RelA) subunit of the transcription factor nuclear factor kappaB (NF-kappaB), which activates various target genes involved in inflammation, apoptosis, and embryonic development. The interaction between AES and p65 was confirmed by in vitro glutathione S-transferase pull down assay and by in vivo co-immunoprecipitation study. In transient transfection assays, AES repressed p65-driven gene expression. AES also inhibited NF-kappaB-dependent gene expression induced by tumor necrosis factor alpha, interleukin-1beta, and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1, which is an upstream kinase for NF-kappaB activation. These data indicate that AES acts as a corepressor for NF-kappaB and suggest that AES may play a pivotal role in the regulation of NF-kappaB target genes."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.6.4383"xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.6.4383"xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Okamoto T."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Okamoto T."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Ono T."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Ono T."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Imai H."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Imai H."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Asamitsu K."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Asamitsu K."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Sonta S."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Sonta S."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Tetsuka T."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Tetsuka T."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Uranishi H."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/author | "Uranishi H."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10660609 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |