| http://purl.uniprot.org/citations/10662672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10662672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10662672 | http://www.w3.org/2000/01/rdf-schema#comment | "The Escherichia coli RuvA and RuvB proteins promote the branch migration of Holliday junctions during the late stages of homologous recombination and DNA repair (reviewed in [1]). Biochemical and structural studies of the RuvAB-Holliday junction complex have shown that RuvA binds directly to the Holliday junction [2] [3] [4] [5] [6] and acts as a specificity factor that promotes the targeting of RuvB [7] [8], a hexameric ring protein that drives branch migration [9] [10] [11]. Electron microscopic visualisation of the RuvAB complex revealed that RuvA is flanked by two RuvB hexamers, which bind DNA arms that lie diametrically opposed across the junction [8]. ATP-dependent branch migration occurs as duplex DNA is pumped out through the centre of each ring. Because RuvB possesses well-conserved helicase motifs and RuvAB exhibits a 5'-3' DNA helicase activity in vitro [12], the mechanism of branch migration is thought to involve DNA opening within the RuvB ring, which provides a single strand for the unidirectional translocation of the protein along DNA. We have investigated whether the RuvB ring can translocate along duplex DNA containing a site-directed interstrand psoralen crosslink. Surprisingly, we found that the crosslink failed to inhibit branch migration. We interpret these data as evidence against a base-by-base tracking model and suggest that extensive DNA opening within the RuvB ring is not required for DNA translocation by RuvB."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)00296-7"xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)00296-7"xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Kuraoka I."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Kuraoka I."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "George H."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "George H."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Wood R.D."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Wood R.D."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Kobertz W.R."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Kobertz W.R."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Nauman D.A."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/author | "Nauman D.A."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/pages | "103-106"xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/pages | "103-106"xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/title | "RuvAB-mediated branch migration does not involve extensive DNA opening within the RuvB hexamer."xsd:string |
| http://purl.uniprot.org/citations/10662672 | http://purl.uniprot.org/core/title | "RuvAB-mediated branch migration does not involve extensive DNA opening within the RuvB hexamer."xsd:string |