| http://purl.uniprot.org/citations/10669747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10669747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10669747 | http://www.w3.org/2000/01/rdf-schema#comment | "The neurofibromatosis type 2 (NF2) protein, known as schwannomin or merlin, is a tumor suppressor involved in NF2-associated and sporadic schwannomas and meningiomas. It is closely related to the ezrin-radixin-moesin family members, implicated in linking membrane proteins to the cytoskeleton. The molecular mechanism allowing schwannomin to function as a tumor suppressor is unknown. In attempt to shed light on schwannomin function, we have identified a novel coiled-coil protein, SCHIP-1, that specifically associates with schwannomin in vitro and in vivo. Within its coiled-coil region, this protein is homologous to human FEZ proteins and the related Caenorhabditis elegans gene product UNC-76. Immunofluorescent staining of transiently transfected cells shows a partial colocalization of SCHIP-1 and schwannomin, beneath the cytoplasmic membrane. Surprisingly, immunoprecipitation assays reveal that in a cellular context, association with SCHIP-1 can be observed only with some naturally occurring mutants of schwannomin, or a schwannomin spliced isoform lacking exons 2 and 3, but not with the schwannomin isoform exhibiting growth-suppressive activity. Our observations suggest that SCHIP-1 interaction with schwannomin is regulated by conformational changes in schwannomin, possibly induced by posttranslational modifications, alternative splicing, or mutations."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.5.1699-1712.2000"xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.5.1699-1712.2000"xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Camonis J."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Camonis J."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Goutebroze L."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Goutebroze L."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Muchardt C."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Muchardt C."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Brault E."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/author | "Brault E."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/pages | "1699-1712"xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/pages | "1699-1712"xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/title | "Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/title | "Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins."xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10669747 | http://purl.uniprot.org/core/volume | "20"xsd:string |