| http://purl.uniprot.org/citations/10671565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10671565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10671565 | http://www.w3.org/2000/01/rdf-schema#comment | "Two forms of glutamic-acid decarboxylase (GAD) have been identified in mammalian tissues: a 65-kDa form (GAD65) and a 67-kDa form (GAD67). Alternate splicing produces one or two smaller variants of GAD67 in the brain of embryonic mice and rats. Additionally, a short, heretofore unidentified transcript homologous to GAD67 has been detected in human testis RNA. Because GAD, the enzyme responsible for gamma-aminobutyric acid production and a key autoantigen in type I diabetes, has unclear function in non-neural tissue, it is important to understand its pattern of expression. Unlike GAD65, GAD67 is not produced in human pancreatic islets. Here, we describe a novel splice variant of GAD67 that is produced in human islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. This transcript directs the synthesis of a protein without GAD enzymatic activity: GAD25. A unique peptide sequence at the carboxyl terminus of GAD25 is highly conserved between mice, rats, and humans. We conclude that humans produce a third form of GAD in non-neural tissues and that human islets, although they do not synthesize full-length GAD67, do express this shortened variant."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.7.5188"xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.7.5188"xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/author | "Chessler S.D."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/author | "Chessler S.D."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/author | "Lernmark A."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/author | "Lernmark A."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/pages | "5188-5192"xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/pages | "5188-5192"xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/title | "Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/title | "Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues."xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10671565 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10671565 |
| http://purl.uniprot.org/citations/10671565 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10671565 |
| http://purl.uniprot.org/citations/10671565 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10671565 |
| http://purl.uniprot.org/citations/10671565 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10671565 |
| http://purl.uniprot.org/uniprot/Q99259 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10671565 |
| http://purl.uniprot.org/uniprot/#_kb.Q99259_up.isolatedFrom_tissue.1030 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10671565 |