| http://purl.uniprot.org/citations/10673397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10673397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10673397 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin A is indispensable for S phase cell cycle progression and is suggested to be a crucial target of cell adhesion signals. In this study, we demonstrate that beta3-endonexin, a molecule known to associate with the integrin beta3 cytoplasmic domain, specifically binds cyclin A. Deletion of the amino-terminal 52-amino-acid residues including the cyclin-binding RxL motif abolishes the ability of beta3-endonexin to interact with cyclin A. In an in vitro kinase assay, beta3-endonexin inhibits pRB kinase activity associated with cyclin A-Cdk2 while leaving its histone H1 kinase activity unaffected. Coexpression of beta3-endonexin in yeast cells overcomes growth suppression caused by an activation of cyclin A-associated kinase. Our results indicate that beta3-endonexin is a novel cyclin A-binding molecule that regulates cyclin A-associated pRB kinase activity."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.2007"xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.2007"xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Yamada M."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Maeda T."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Maeda T."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Ohtoshi A."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Ohtoshi A."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Hatakeyama M."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Hatakeyama M."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Higashi H."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Higashi H."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Ashizawa S."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/author | "Ashizawa S."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/pages | "947-952"xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/pages | "947-952"xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/title | "Beta3-endonexin as a novel inhibitor of cyclin A-associated kinase."xsd:string |
| http://purl.uniprot.org/citations/10673397 | http://purl.uniprot.org/core/title | "Beta3-endonexin as a novel inhibitor of cyclin A-associated kinase."xsd:string |