| http://purl.uniprot.org/citations/10678181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10678181 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF1 tumor suppressor gene encodes neurofibromin, a GTPase-activating protein (GAP) for p21ras (Ras). Children with NF1 are predisposed to juvenile myelomonocytic leukemia (JMML). Some heterozygous Nf1 mutant mice develop a similar myeloproliferative disorder (MPD), and adoptive transfer of Nf1-deficient fetal liver cells consistently induces this MPD. Human JMML and murine Nf1-deficient cells are hypersensitive to granulocyte-macrophage colony-stimulating factor (GM-CSF) in methylcellulose cultures. We generated hematopoietic cells deficient in both Nf1 and Gmcsf to test whether GM-CSF is required to drive excessive proliferation of Nf1-/-cells in vivo. Here we show that GM-CSF play a central role in establishing and maintaining the MPD and that recipients engrafted with Nf1-/- Gmcsf-/-hematopoietic cells are hypersensitive to exogenous GM-CSF."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80415-3"xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Zhang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Jacks T."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Shannon K.M."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Birnbaum R.A."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Dranoff G."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Clapp D.W."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "Wardak Z."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/author | "O'Marcaigh A."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/pages | "189-195"xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/title | "Nf1 and Gmcsf interact in myeloid leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/10678181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10678181 |
| http://purl.uniprot.org/citations/10678181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10678181 |
| http://purl.uniprot.org/uniprot/P01587#attribution-26EDEFF59C475A43E4B8B4E6330890A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10678181 |
| http://purl.uniprot.org/uniprot/Q04690#attribution-26EDEFF59C475A43E4B8B4E6330890A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10678181 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P863-mappedCitation-10678181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10678181 |
| http://purl.uniprot.org/uniprot/#_Q14AD9-mappedCitation-10678181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10678181 |
| http://purl.uniprot.org/uniprot/#_Q3TYD2-mappedCitation-10678181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10678181 |
| http://purl.uniprot.org/uniprot/#_Q04690-mappedCitation-10678181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10678181 |
| http://purl.uniprot.org/uniprot/#_Q8BQG3-mappedCitation-10678181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10678181 |