| http://purl.uniprot.org/citations/10679081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10679081 | http://www.w3.org/2000/01/rdf-schema#comment | "The nonobese diabetic (NOD) mouse spontaneously develops autoimmune insulin-dependent diabetes mellitus and serves as a model for human type I diabetes. NOD spleen cells proliferate to a lesser extent than those from C57BL/6 and BALB/c mice in response to anti-CD3. To investigate the cause of this reduced T cell proliferation, costimulatory molecule expression was investigated. It was found that NOD macrophages, dendritic cells, and T cells, but not B cells, expressed lower basal levels of CD86, but not CD80, CD28, or CD40, compared with C57BL/6 and BALB/c. This low CD86 expression was not dependent on the MHC haplotype or on diabetes development since the NOD-related, diabetes-free mouse strains NON (H-2nb1) and NOR (H-2g7) exhibited similar low levels of CD86 expression and proliferation. Furthermore, following activation, the relative up-regulation of CTLA-4, as compared with CD28, was more pronounced on C57BL/6 and BALB/c T cells as shown by an increased CTLA-4/CD28 ratio. This activation-induced increase in the CTLA-4/CD28 ratio was markedly reduced on NOD T cells compared with the other two strains. The low CD86 expression in NOD mice may account for the reduced increase in both proliferation and the CTLA-4/CD28 ratio, since reducing CD86 expression in C57BL/6 and BALB/c cultures to NOD levels significantly reduces the proliferation and the CTLA-4/CD28 ratio. Therefore, we propose that a low level of CD86 expression in the NOD mouse contributes to a defective regulation of autoreactive T cells by preventing the full activation of T cells and therefore the up-regulation of CTLA-4."xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.5.2444"xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/author | "Hedlund G."xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/author | "Dahlen E."xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/author | "Dawe K."xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/pages | "2444-2456"xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/title | "Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation."xsd:string |
| http://purl.uniprot.org/citations/10679081 | http://purl.uniprot.org/core/volume | "164"xsd:string |
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