| http://purl.uniprot.org/citations/10679295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10679295 | http://www.w3.org/2000/01/rdf-schema#comment | "Jagged-Notch interactions regulate a transmembrane ligand-receptor signaling pathway involved in the regulation of cell fate determination as well as myoblast and endothelial cell differentiation. To further examine the role of the transmembrane ligand, Jagged-1, in the regulation of cell differentiation, we stably transfected NIH 3T3 cells with a truncated form of Jagged(J)-1, which results in the secretion of a soluble(s) form of the protein. Comparison of gene expression by serial analysis demonstrated that among the 227 transcripts differentially regulated in the sJ-1 transfectants, the expression of the pro-alpha-2(I) collagen transcript and pro-alpha-1(I) collagen translation product was predominantly repressed in sJ-1 transfectants. When plated on extracellular matrices, sJ-1 transfectants formed prominent chord-like structures on type I collagen but not on fibrin, fibronectin, or vitronectin. While the sJ-1 transfectants exhibited growth kinetics similar to control cells and were unable to grow in soft agar, the cells were less sensitive to contact inhibition of growth in vitro and sJ-1 allografts formed tissue masses in nude mice after a prolonged latency period and exhibited an abundance of host-derived microvascular endothelial cells. These data suggest that J-1 may be able to modulate, in a matrix-dependent manner, the organization of cell to cell interactions including its ability to promote the development of chord-like structures."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2000.2173"xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Liaw L."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Maciag T."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Small D."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Booth C."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Prudovsky I."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Wong M.K."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Mousa S."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/author | "Vary C."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/pages | "853-859"xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/title | "A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures."xsd:string |
| http://purl.uniprot.org/citations/10679295 | http://purl.uniprot.org/core/volume | "268"xsd:string |
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