| http://purl.uniprot.org/citations/10681424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10681424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10681424 | http://www.w3.org/2000/01/rdf-schema#comment | "Induction of wild-type p53 in mouse fibroblasts causes cell cycle arrest at the G(1) phase, whereas coexpression of p53 and the protooncogene c-myc induces apoptosis. Although p53 transcriptional activity generally is required for both pathways, the molecular components mediating p53-dependent apoptosis are not well understood. To identify factors that could mediate p53-induced cell death, we used a comparative RNA differential display procedure. We have identified Pw1/Peg3 as a gene product induced during p53/c-myc-mediated apoptosis. Pw1/Peg3 is not induced during p53-mediated G(1) growth arrest nor by c-myc alone. Although it is not clear whether the induction of Pw1/Peg3 depends on p53 activity, we show that Pw1/Peg3 interacts with a p53-inducible gene product Siah1a. We demonstrate that coexpression of Pw1/Peg3 with Siah1a induces apoptosis independently of p53 whereas expression of Pw1/Peg3 or Siah1a separately has no effect on cell death. These data suggest that Siah1a and Pw1/Peg3 cooperate in the p53-mediated cell death pathway. Furthermore, we show that inhibiting Pw1/Peg3 activity blocks p53-induced apoptosis. The observation that Pw1/Peg3 is necessary for the p53 apoptotic response suggests a pivotal role for this gene in determining cell death versus survival."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.040378897"xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.040378897"xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Pan J."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Pan J."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Wei X."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Wei X."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Sassoon D.A."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Sassoon D.A."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Bowtell D.D."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Bowtell D.D."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Relaix F."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/author | "Relaix F."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10681424 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |