| http://purl.uniprot.org/citations/10692437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10692437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10692437 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we characterize a novel murine nuclear protein, which we named NBP-45, that is related to the ubiquitous nuclear proteins HMG-14/-17, binds specifically to nucleosome core particles, and can function as a transcriptional activator. NBP-45 mRNA is expressed at low levels and in variable amounts in all mouse tissues tested but is especially abundant in RNA extracted from 7-day-old mouse embryos, suggesting that it functions in early embryonic development. NBP-45 is composed of 406 amino acids and is encoded by a single size transcript. The region spanning the N-terminal 85 amino acids contains three segments that are highly homologous to functionally important domains in the HMG-14/-17 protein family: the nuclear localization signal, the nucleosome binding domain, and the chromatin unfolding domain. The protein region spanning the C-terminal 321 amino acids has a 42% content of negatively charged residues. The first 23 amino acids contain a region necessary for nuclear entry of the protein, the region spanning residues 12-40 is the main nucleosomal binding domain of the protein, and the negatively charged, C-terminal domain is necessary for transcription activation. The functional domains of NBP-45 are indicative of a nuclear protein that binds to nucleosomes, thereby creating a chromatin region of high local negative charge. Our studies establish the nucleosomal binding domain as a protein motif that is present in other than just the ubiquitous HMG-14/-17 proteins. We suggest that the nucleosomal binding domain motif is a protein module that facilitates binding to nucleosomes in chromatin."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.9.6368"xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.9.6368"xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Landsman D."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Landsman D."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Bustin M."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Bustin M."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Postnikov Y.V."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Postnikov Y.V."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Shirakawa H."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/author | "Shirakawa H."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/pages | "6368-6374"xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/pages | "6368-6374"xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/title | "NBP-45, a novel nucleosomal binding protein with a tissue-specific and developmentally regulated expression."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/title | "NBP-45, a novel nucleosomal binding protein with a tissue-specific and developmentally regulated expression."xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10692437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10692437 |
| http://purl.uniprot.org/citations/10692437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10692437 |