| http://purl.uniprot.org/citations/10699173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10699173 | http://www.w3.org/2000/01/rdf-schema#comment | "Huntington's disease (HD) is caused by an expanded N-terminal glutamine tract that endows huntingtin with a striatal-selective structural property ultimately toxic to medium spiny neurons. In precise genetic models of juvenile HD, HdhQ92 and HdhQ111 knock-in mice, long polyglutamine segments change huntingtin's physical properties, producing HD-like in vivo correlates in the striatum, including nuclear localization of a version of the full-length protein predominant in medium spiny neurons, and subsequent formation of N-terminal inclusions and insoluble aggregate. These changes show glutamine length dependence and dominant inheritance with recruitment of wild-type protein, critical features of the altered HD property that strongly implicate them in the HD disease process and that suggest alternative pathogenic scenarios: the effect of the glutamine tract may act by altering interaction with a critical cellular constituent or by depleting a form of huntingtin essential to medium spiny striatal neurons."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/9.4.503"xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Yi H."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "White J.K."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Gusella J.F."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Li X.J."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Li S.H."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "MacDonald M.E."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Joyner A.L."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Weaver M."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Vrbanac V."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Gutekunst C.A."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Auerbach W."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Vonsattel J.P."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Wheeler V.C."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/author | "Hersch S."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/pages | "503-513"xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/title | "Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice."xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/10699173 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10699173 |
| http://purl.uniprot.org/citations/10699173 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10699173 |
| http://purl.uniprot.org/uniprot/P42859#attribution-BFB834433B62C1867632888268EC5DED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10699173 |