| http://purl.uniprot.org/citations/10701873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10701873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10701873 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural correlates of long-term sensitization of defensive withdrawal reflexes in Aplysia occur in sensory neurons in the pleural ganglia and can be mimicked by exposure of these neurons to serotonin (5-HT). Studies using inhibitors indicate that transcription is necessary for production of long-term facilitation by 5-HT. Several mRNAs that change in response to 5-HT have been identified, but the molecular events responsible for long-term facilitation have not yet been fully described. To detect additional changes in mRNAs, we investigated the effects of 5-HT (1.5 hr) on levels of mRNA in pleural-pedal ganglia using in vitro translation. Four mRNAs were affected by 5-HT, three of which were identified as calmodulin (CaM), phosphoglycerate kinase (PGK), and a novel gene product (protein 3). Using RNase protection assays, we found that 5-HT increased all three mRNAs in the pleural sensory neurons. CaM and protein 3 mRNAs were also increased in the sensory neurons by sensitization training. Furthermore, stimulation of peripheral nerves of pleural-pedal ganglia, an in vitro analog of sensitization training, increased the incorporation of labeled amino acids into CaM, PGK, and protein 3. These results indicate that increases in CaM, PGK, and protein 3 are part of the early response of sensory neurons to stimuli that produce long-term facilitation, and that CaM and protein 3 could have a role in the generation of long-term sensitization."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.org/dc/terms/identifier | "doi:10.1101/lm.4.6.478"xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.org/dc/terms/identifier | "doi:10.1101/lm.4.6.478"xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Ren X."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Ren X."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Homayouni R."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Homayouni R."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Hattar S."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Hattar S."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Crow M.T."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Crow M.T."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Noel F."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Noel F."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Eskin A."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Eskin A."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Byrne J.H."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Byrne J.H."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Nunez-Regueiro M."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Nunez-Regueiro M."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Macphee K."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "Macphee K."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "West H."xsd:string |
| http://purl.uniprot.org/citations/10701873 | http://purl.uniprot.org/core/author | "West H."xsd:string |