| http://purl.uniprot.org/citations/10708949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/10708949 | http://www.w3.org/2000/01/rdf-schema#comment | "Smads are signal transducers for the members of the transforming growth factor-beta (TGF-beta) superfamily. Bone morphogenetic proteins (BMPs) and their receptors induce differentiation of C2C12 cells into osteoblast-like cells. Using an adenoviral expression vector system, we showed that receptor-regulated Smads (R-Smads) activated by BMPs can induce the differentiation of C2C12 cells. Inhibitory Smads (I-Smads) interfere with the osteoblast differentiation of C2C12 cells by preventing the nuclear translocation of R-Smads. After translocation into the nucleus, Smad oligomers regulate the transcription of target genes through binding to DNA directly, interaction with other DNA binding proteins, and recruitment of transcriptional co-activators or co-repressors. Through interaction with different transcription factors and transcriptional co-activators or co-repressors, Smads may exhibit specific effects in various cell types."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1359-6101(99)00025-8"xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1359-6101(99)00025-8"xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/name | "Cytokine Growth Factor Rev."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/name | "Cytokine Growth Factor Rev."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/pages | "15-22"xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/pages | "15-22"xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/title | "TGF-beta signaling by Smad proteins."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/title | "TGF-beta signaling by Smad proteins."xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10708949 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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| http://purl.uniprot.org/citations/10708949 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10708949 |
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| http://purl.uniprot.org/uniprot/O43541 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10708949 |
| http://purl.uniprot.org/uniprot/Q15796 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10708949 |
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| http://purl.uniprot.org/uniprot/Q15797 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10708949 |