| http://purl.uniprot.org/citations/10710310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10710310 | http://www.w3.org/2000/01/rdf-schema#comment | "Chk2 is a protein kinase that is activated in response to DNA damage and may regulate cell cycle arrest. We generated Chk2-deficient mouse cells by gene targeting. Chk2-/-embryonic stem cells failed to maintain gamma-irradiation-induced arrest in the G2 phase of the cell cycle. Chk2-/-thymocytes were resistant to DNA damage-induced apoptosis. Chk2-/-cells were defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation. Reintroduction of the Chk2 gene restored p53-dependent transcription in response to gamma irradiation. Chk2 directly phosphorylated p53 on serine 20, which is known to interfere with Mdm2 binding. This provides a mechanism for increased stability of p53 by prevention of ubiquitination in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.287.5459.1824"xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Matsuoka S."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Wakeham A."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Ruland J."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Hirao A."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/author | "Kong Y.Y."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/pages | "1824-1827"xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/title | "DNA damage-induced activation of p53 by the checkpoint kinase Chk2."xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/10710310 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10710310 |
| http://purl.uniprot.org/citations/10710310 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10710310 |
| http://purl.uniprot.org/uniprot/Q62388#attribution-8FB3B5569E65A53AF7B2607A67FE5324 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10710310 |
| http://purl.uniprot.org/uniprot/P39689#attribution-8FB3B5569E65A53AF7B2607A67FE5324 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10710310 |
| http://purl.uniprot.org/uniprot/Q9Z265#attribution-00C483557E05436A0891D01CF989642C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10710310 |
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| http://purl.uniprot.org/uniprot/P02340#attribution-8FB3B5569E65A53AF7B2607A67FE5324 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10710310 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDS0-mappedCitation-10710310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10710310 |