| http://purl.uniprot.org/citations/10712908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10712908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10712908 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 serine/threonine protein phosphatases (PP1) are important regulators of many cellular and developmental processes, including glycogen metabolism, muscle contraction, and the cell cycle [1] [2] [3] [4] [5]. Drosophila and humans both have multiple genes encoding PP1 isoforms [3] [6] [7]; each has one beta and several alpha isoform genes (alpha(1), alpha(2), alpha(3) in flies, alpha and gamma in humans; mammalian PP1beta is also known as PP1delta). The alpha/beta subtype differences are highly conserved between flies and mammals [6]. Though all these proteins are >85% identical to each other and have indistinguishable activities in vitro, we show here that the Drosophila beta isoform has a distinct biological role. We show that PP1beta9C corresponds to flapwing (flw), previously identified mutants of which are viable but flightless because of defects in indirect flight muscles (IFMs) [8]. We have isolated a new, semi-lethal flw allele that shows a range of defects, especially in muscles, which break away from their attachment sites and degenerate."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)00364-x"xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(00)00364-x"xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Fernandes J."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Fernandes J."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Thomas D."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Thomas D."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Gross S."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Gross S."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Turner J."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Turner J."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Raghavan S."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Raghavan S."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Morgan G."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Morgan G."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Alphey L."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Alphey L."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Szoor B."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Szoor B."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Williams I."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Williams I."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Aslam H."xsd:string |
| http://purl.uniprot.org/citations/10712908 | http://purl.uniprot.org/core/author | "Aslam H."xsd:string |