| http://purl.uniprot.org/citations/10722583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10722583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10722583 | http://www.w3.org/2000/01/rdf-schema#comment | "In gram-negative bacteria, high-affinity iron uptake requires the TonB/ExbB/ExbD envelope complex to release iron chelates from their specific outer membrane receptors into the periplasm. Based on sequence similarities, the Bordetella pertussis tonB exbB exbD locus was identified on a cloned DNA fragment. The tight organization of the three genes suggests that they are cotranscribed. A putative Fur-binding sequence located upstream from tonB was detected in a Fur titration assay, indicating that the tonB exbB exbD operon may be Fur-repressed in high-iron growth conditions. Putative structural genes of the beta-subunit of the histone-like protein HU and of a new two-component regulatory system were identified upstream from tonB and downstream from exbD, respectively. A B. pertussis DeltatonB exbB::Km(r) mutant was constructed by allelic exchange and characterized. The mutant was impaired for growth in low-iron medium in vitro and could not use ferrichrome, desferal, or hemin as iron sources. Levels of production of the major bacterial toxins and adhesins were similar in the TonB(+)/TonB(-) pair. The DeltatonB exbB mutant was still responsive to chemical modulators of virulence; thus, the BvgA/BvgS two-component system is not TonB dependent. Nevertheless, in vivo in the mouse respiratory infection model, the colonization ability of the mutant was reduced compared to the parental strain."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.68.4.1919-1927.2000"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.68.4.1919-1927.2000"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.org/dc/terms/identifier | "doi:10.1128/IAI.68.4.1919-1927.2000"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Locht C."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Locht C."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Pradel E."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Pradel E."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Guiso N."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Guiso N."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Menozzi F.D."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/author | "Menozzi F.D."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/name | "Infect. Immun."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/name | "Infect. Immun."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/pages | "1919-1927"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/pages | "1919-1927"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/title | "Bordetella pertussis TonB, a Bvg-independent virulence determinant."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/title | "Bordetella pertussis TonB, a Bvg-independent virulence determinant."xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/10722583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10722583 |