| http://purl.uniprot.org/citations/10722704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10722704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10722704 | http://www.w3.org/2000/01/rdf-schema#comment | "ErbB4 is a member of the epidermal growth factor receptor (ErbB) family that mediates cellular responses activated by neuregulins (NRG) and other epidermal growth factor-like growth factors. Two naturally occurring ErbB4 isoforms, ErbB4 CYT-1 and ErbB4 CYT-2, have previously been identified. Unlike ErbB4 CYT-1, ErbB4 CYT-2 lacks a phosphoinositide 3-kinase (PI3-K)-binding site and is incapable of activating PI3-K. We have now examined the consequences of the inability of this isoform to activate PI3-K on cell proliferation, survival, and chemotaxis in response to NRG-1beta: (i) NRG-1beta stimulated proliferation of cells expressing either ErbB4 CYT-1 or ErbB4 CYT-2. Consistent with the mitogenic responsiveness, analysis of downstream signaling showed that Shc and MAPK were phosphorylated after stimulating either isoform with NRG-1beta. (ii) NRG-1beta protected cells expressing ErbB4 CYT-1 but not cells expressing ErbB4 CYT-2 from starvation-induced apoptosis as measured by effects on cell number and 4', 6-diamidino-2-phenylindole staining. Furthermore, in cells expressing ErbB4 CYT-2, Akt, a protein kinase that mediates cell survival, was not phosphorylated. (iii) NRG-1beta stimulated chemotaxis and membrane ruffling in cells expressing ErbB4 CYT-1 but not in cells expressing ErbB4 CYT-2. In summary, ErbB4 CYT-2 can mediate proliferation but not chemotaxis or survival. These results suggest a novel mechanism by which cellular responses such as chemotaxis and survival may be regulated by the expression of alternative receptor-tyrosine kinase isoforms that differ in their coupling to PI3-K signaling."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.12.8641"xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.12.8641"xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Sundvall M."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Sundvall M."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Elenius K."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Elenius K."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Kainulainen V."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Kainulainen V."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Klagsbrun M."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Klagsbrun M."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Maatta J.A."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Maatta J.A."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Santiestevan E."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/author | "Santiestevan E."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/pages | "8641-8649"xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/pages | "8641-8649"xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/title | "A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis."xsd:string |
| http://purl.uniprot.org/citations/10722704 | http://purl.uniprot.org/core/title | "A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis."xsd:string |