| http://purl.uniprot.org/citations/10722740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10722740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10722740 | http://www.w3.org/2000/01/rdf-schema#comment | "APP-BP1 binds to the amyloid precursor protein (APP) carboxyl-terminal domain. Recent work suggests that APP-BP1 participates in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8. We show here that, in vivo in mammalian cells, APP-BP1 interacts with hUba3, its presumptive partner in the NEDD8 activation pathway, and that the APP-BP1 binding site for hUba3 is within amino acids 443-479. We also provide evidence that the human APP-BP1 molecule can rescue the ts41 mutation in Chinese hamster cells. This mutation previously has been shown to lead to successive S phases of the cell cycle without intervening G(2), M, and G(1), suggesting that the product of this gene negatively regulates entry into the S phase and positively regulates entry into mitosis. We show that expression of APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and that this function requires both hUba3 and hUbc12. Overexpression of APP-BP1 in primary neurons causes apoptosis via the same pathway. A specific caspase-6 inhibitor blocks this apoptosis. These findings are discussed in the context of abnormalities in the cell cycle that have been observed in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.12.8929"xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.12.8929"xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "Hirschberg J."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "Hirschberg J."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "McPhie D.L."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/author | "McPhie D.L."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/pages | "8929-8935"xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/pages | "8929-8935"xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/title | "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/title | "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons."xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10722740 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10722740 |
| http://purl.uniprot.org/citations/10722740 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10722740 |