| http://purl.uniprot.org/citations/10724160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10724160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10724160 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of the GTPase-binding domain of WASP, which can be induced by the C-terminal region or by organic co-solvents. In the autoinhibited complex, intramolecular interactions with the GTPase-binding domain occlude residues of the C terminus that regulate the Arp2/3 actin-nucleating complex. Binding of Cdc42 to the GTPase-binding domain causes a dramatic conformational change, resulting in disruption of the hydrophobic core and release of the C terminus, enabling its interaction with the actin regulatory machinery. These data show that 'intrinsically unstructured' peptides such as the GTPase-binding domain of WASP can be induced into distinct structural and functional states depending on context."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.org/dc/terms/identifier | "doi:10.1038/35004513"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.org/dc/terms/identifier | "doi:10.1038/35004513"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Rosen M.K."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Rosen M.K."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Kim A.S."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Kim A.S."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Liu G.A."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Liu G.A."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Abdul-Manan N."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Abdul-Manan N."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Kakalis L.T."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/author | "Kakalis L.T."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/pages | "151-158"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/pages | "151-158"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/title | "Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/title | "Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein."xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/volume | "404"xsd:string |
| http://purl.uniprot.org/citations/10724160 | http://purl.uniprot.org/core/volume | "404"xsd:string |