| http://purl.uniprot.org/citations/10731090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10731090 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone resorption overlying a developing tooth is a necessary event in the creation of an eruption pathway. The formation and function of osteoclasts, which play a major role in bone resorption, are controlled by several factors. Although CSF-1 and its mRNA are expressed in dental follicle cells required for eruption, little is known about the contribution of CSF-1 to osteoclast formation on the bony crypt around the tooth germ. The receptor protein of the CSF-1 encoded proto-oncogene c-fms was identified on multinucleated cells adjacent to the dental follicle, in conjunction with TRAP staining as a marker enzyme for osteoclasts in rat. c-Fms was highly expressed in TRAP-positive multinuclear cells at 3 days postnatal and the number of c-Fms-expressing cells was reduced thereafter. Administration of IL-1alpha, which enhances formation and function of osteoclasts, caused an increase in the number of c-Fms and TRAP-positive cells in rat. On the contrary, injection of calcitonin, which depresses osteoclast formation, caused a decrease in the number. It is obvious that the receptor of CSF-1 is expressed on the surface of osteoclasts around the tooth germ, on the dental follicle. These findings suggested that CSF-1 directly enhances the influx of osteoclasts adjacent to the erupting tooth, resulting in the formation of an eruption pathway."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/author | "Nakagawa K."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/author | "Kuroda S."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/author | "Takada K."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/author | "Yamashita K."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/author | "Kawakami M."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/author | "Yoshida C.A."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/name | "J Craniofac Genet Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/pages | "213-220"xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/title | "Expression of CSF-1 receptor on TRAP-positive multinuclear cells around the erupting molars in rats."xsd:string |
| http://purl.uniprot.org/citations/10731090 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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