| http://purl.uniprot.org/citations/10733010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10733010 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of 5-hydroxytryptamine-2B (5-HT2B) receptor mRNA has recently been shown in cultured astrocytes. Here the expression of functional 5-HT2B receptors has been studied in cultured astrocytes from rat cerebral cortex, hippocampus, and brain stem. Fluo-3- and fura-2-based microspectrofluorometry was used for measuring changes in intracellular free calcium concentrations ([Ca2+]i). The 5-HT2B agonist alpha-methyl 5-HT (40 nM) produced rapid transient increases in [Ca2+]i in astrocytes from all three brain regions studied, and these responses were blocked by the selective 5-HT2B antagonist rauwolscine (1 microM). The specificity of the responses to alpha-methyl 5-HT was further demonstrated by the failure of 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate (1 microM), a specific 5-HT2A/5-HT2C antagonist, to block these responses. The 5-HT2B-induced increases in [Ca2+]i persisted in Ca2+-free buffer, indicating that the increase in [Ca2+]i results from mobilization of intracellular Ca2+ stores. The expression of 5-HT2B receptors on astroglial cells was further verified immunohistochemically and by Western blot analysis. These results provide evidence of the existence of 5-HT2B receptors on astrocytes in primary culture."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0197-0186(99)00134-5"xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/author | "Hansson E."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/author | "Blomstrand F."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/author | "Persson P.A."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/author | "Sanden N."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/author | "Thorlin T."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/name | "Neurochem Int"xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/pages | "427-434"xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/title | "5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions."xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/10733010 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10733010 |
| http://purl.uniprot.org/citations/10733010 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10733010 |
| http://purl.uniprot.org/uniprot/#_G3V8A0-mappedCitation-10733010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10733010 |
| http://purl.uniprot.org/uniprot/#_P30994-mappedCitation-10733010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10733010 |
| http://purl.uniprot.org/uniprot/G3V8A0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10733010 |
| http://purl.uniprot.org/uniprot/P30994 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10733010 |