| http://purl.uniprot.org/citations/10733900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10733900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10733900 | http://www.w3.org/2000/01/rdf-schema#comment | "CrkII is an intracellular adaptor protein involved in signal transduction by various growth factors. Activation of PDGF alpha-receptor resulted in its association with CrkII in vivo. In contrast, binding of CrkII to the PDGF beta-receptor was negligible, despite its becoming prominently phosphorylated. Bacterially expressed GST-CrkII SH2 domain specifically bound to Tyr-762 and Tyr-771 in the activated PDGF alpha- and beta-receptors, respectively. GST fusion protein of full-length CrkII also bound to the activated PDGF beta-receptor. However, tyrosine phosphorylation of GST-CrkII diminished its binding to the beta-receptor. CrkI, a truncated version of CrkII lacking the phosphorylatable tyrosine residue, could bind to both PDGF alpha- and beta-receptors in vivo. In conclusion, tyrosine phosphorylation of CrkII negatively affects its binding to the PDGF receptors. The differential binding of CrkII to the PDGF alpha- and beta-receptors may be a rationale for functional diversity between the two receptors."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2000.2374"xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2000.2374"xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Hashimoto Y."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Hashimoto Y."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Matsumoto T."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Mori S."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Mori S."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Takemoto M."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Takemoto M."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Yokote K."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Yokote K."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Asaumi S."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Asaumi S."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Take A."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/author | "Take A."xsd:string |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10733900 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |