| http://purl.uniprot.org/citations/10737774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10737774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10737774 | http://www.w3.org/2000/01/rdf-schema#comment | "Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and reduced platelet alpha- and delta-granule contents. Here we show by positional cloning that gm results from a G-->A substitution mutation in a splice acceptor site within the alpha-subunit of Rab geranylgeranyl transferase (Rabggta), an enzyme that attaches geranylgeranyl groups to Rab proteins. Most Rabggta mRNAs from gm tissues skipped exon 1 and lacked a start codon. Rabggta protein and Rab geranylgeranyl transferase (GGTase) activity were reduced 4-fold in gm platelets. Geranylgeranylation and membrane association of Rab27, a Rab GGTase substrate, were significantly decreased in gm platelets. These findings indicate that geranylgeranylation of Rab GTPases is critical for hemostasis. Rab GGTase inhibition may represent a new treatment for thrombocytosis and clotting disorders."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.080517697"xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.080517697"xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Detter J.C."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Swank R.T."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Swank R.T."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Mishra V.S."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Mishra V.S."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Seabra M.C."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Seabra M.C."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Tchernev V.T."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Tchernev V.T."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Wallace M.R."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Wallace M.R."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Mules E.H."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "Mules E.H."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "McMurtrie E.B."xsd:string |
| http://purl.uniprot.org/citations/10737774 | http://purl.uniprot.org/core/author | "McMurtrie E.B."xsd:string |