| http://purl.uniprot.org/citations/10741399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10741399 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine the in vivo role of IL-12 in the development of protective immunity in visceral leishmaniasis caused by Leishmania donovani, we examined the course of L. donovani infection in IL-12-deficient C57BL/6 (IL-12-/-) mice. IL-12-/-mice displayed significantly higher parasite burdens in their livers and spleens than wild-type C57BL/6 mice throughout the course of infection. Despite high parasite burdens, the onset of hepatosplenomegaly was significantly delayed in L. donovani-infected IL-12-/-. Moreover, livers and spleens from IL-12-/-mice displayed significantly less inflammation and poorly formed granulomatous lesions than those from IL-12+/+ mice throughout the course of infection. Antigen-stimulated splenocytes from IL-12-/-mice produced significantly less IFN-gamma but more IL-4 than IL-12+/+ mice. These findings indicate that although endogenous IL-12 is critical for the development of protective immunity to L. donovani, it is also responsible for inducing the significant immunopathology associated with visceral leishmaniasis."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.org/dc/terms/identifier | "doi:10.1002/1521-4141(200003)30:3<834::aid-immu834>3.0.co;2-9"xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "Ghosh S.K."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "Satoskar A.A."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "Rodig S."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "Satoskar A.R."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "David J.R."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "Telford S.R."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/author | "von Lichtenberg F."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/pages | "834-839"xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/title | "IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology."xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/10741399 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10741399 |
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