| http://purl.uniprot.org/citations/10744659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10744659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10744659 | http://www.w3.org/2000/01/rdf-schema#comment | "Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cells by IgE-antigen complex triggers signal transduction cascades leading to the release of inflammatory mediators and production of cytokines, which are critical for the development of allergic reactions. We have identified a novel member of the BASH/SLP-76 immunoreceptor-coupled adaptor family expressed in mast cells, termed MIST (for mast cell immunoreceptor signal transducer), which has later been found to be identical to a recently reported cytokine-dependent hemopoietic cell linker, Clnk. Upon FcepsilonRI cross-linking, MIST/Clnk is tyrosine phosphorylated and associates with signaling proteins, phospholipase Cgamma, Vav, Grb2 and linker for activation of T cells (LAT). Overexpression of a mutant form of MIST/Clnk inhibited FcepsilonRI-mediated degranulation, increase in intracellular Ca(2+), NF-AT activation and phosphorylation of LAT. As a crucial signaling component for FcepsilonRI-induced mast cell degranulation, MIST/Clnk might serve as a target for anti-allergic therapy."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/12.4.573"xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/12.4.573"xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Hayashi K."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Hayashi K."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Hidaka Y."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Hidaka Y."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Goitsuka R."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Goitsuka R."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Kitamura D."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Kitamura D."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Sasanuma H."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Sasanuma H."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Fujimura Y.-C."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Fujimura Y.-C."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Kanazashi H."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Kanazashi H."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Ra C."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Ra C."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Tatsuno A."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/author | "Tatsuno A."xsd:string |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10744659 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |