| http://purl.uniprot.org/citations/10744716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10744716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10744716 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated a novel cell-cell adhesion system localized at cadherin-based adherens junctions (AJs). This system consists of at least nectin, a Ca(2+)-independent immunoglobulin-like adhesion molecule, and afadin, an actin filament-binding protein, that connects nectin to the actin cytoskeleton. Nectin constitutes a family consisting of two members, nectin-1 and -2. We have isolated here a third member of the nectin family and named it nectin-3. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). Like nectin-1 and -2, nectin-3alpha consists of three extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic region with the C-terminal consensus motif for binding to the PDZ domain. Nectin-3alpha formed a cis-homo-dimer and showed Ca(2+)-independent trans-homo-interaction to cause homophilic cell-cell adhesion. Nectin-3alpha furthermore showed trans-hetero-interaction with nectin-1 or -2 but did not form a cis-hetero-dimer with nectin-1 or -2. Nectin-1 did not show trans-hetero-interaction with nectin-2. The affinity of trans-hetero-interaction of nectin-3alpha with nectin-1 or -2 was higher than that of trans-homo-interaction of nectin-1, -2, or -3alpha. Nectin-2 and -3 were ubiquitously expressed, whereas nectin-1 was abundantly expressed in brain. Nectin-3alpha was colocalized with nectin-2 at cadherin-based AJs and interacted with afadin. These results indicate that the nectin family consists of at least three members, nectin-1, -2, and -3, all of which show homophilic and heterophilic cell-cell adhesion activities and are localized at cadherin-based AJs."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.14.10291"xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.14.10291"xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Miyahara M."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Miyahara M."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Nakanishi H."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Nakanishi H."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Tachibana K."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Tachibana K."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Satoh-Horikawa K."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/author | "Satoh-Horikawa K."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10744716 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |