| http://purl.uniprot.org/citations/10744718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10744718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10744718 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted factors that share a common beta-barrel structure and act on target cells by binding to cell surface receptors with immunoglobulin-like folds in their extracellular domain. While numerous members of the FGF family have been discovered, the IL-1 family has remained small and outnumbered by IL-1 receptor homologues. From expressed sequence tag data base searches, we have now identified four additional IL-1 homologues, IL-1H1, IL-1H2, IL-1H3, and IL-1H4. Like most other IL-1/FGFs, these proteins do not contain a hydrophobic leader sequence. IL-1H4 has a propeptide sequence, while IL-1H1, IL-1H2, and IL-1H3 encode only the mature protein. Circular dichroism spectra and thermal stability analysis suggest that IL-1H1 folds similarly to IL-1ra. The novel homologues are not widely expressed in mammals. IL-1H1 is constitutively expressed only in placenta and the squamous epithelium of the esophagus. However, IL-1H1 could be induced in vitro in keratinocytes by interferon-gamma and tumor necrosis factor-alpha and in vivo via a contact hypersensitivity reaction or herpes simplex virus infection. This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.14.10308"xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.14.10308"xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Young P.R."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Young P.R."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Doyle M.L."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Doyle M.L."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Wells G.I."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Wells G.I."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Griswold D.E."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Griswold D.E."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Lehr R."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Lehr R."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Capper E.A."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Capper E.A."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "McDonnell P.C."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "McDonnell P.C."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Tal-Singer R."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Tal-Singer R."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Tierney L."xsd:string |
| http://purl.uniprot.org/citations/10744718 | http://purl.uniprot.org/core/author | "Tierney L."xsd:string |