| http://purl.uniprot.org/citations/10747850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10747850 | http://www.w3.org/2000/01/rdf-schema#comment | "Curcumin (diferuloyl methane), the yellow pigment in turmeric (Curcuma longa), is a potent chemopreventive agent. Curcumin induces apoptosis of several, but not all, cancer cells. Many cancer cells protect themselves against apoptosis by activating nuclear factor-kappaB (NF-kappaB)/Rel, a transcription factor that helps in cell survival. Signal-induced activation of NF-kappaB is known to be inhibited by curcumin. To understand the role of NF-kappaB in curcumin-induced apoptosis, we stably transfected relA gene encoding the p65/RelA subunit of NF-kappaB, into l-929 cells (mouse fibrosarcoma) and the relA-transfected cells were resistant to varying doses of curcumin (10(-6)-10(-4) m), whereas the parental cells underwent apoptosis in a time- and dose-dependent manner. The relA-transfected cells showed constitutive NF-kappaB DNA binding activity that could not be inhibited by curcumin and did not show nuclear condensation and DNA fragmentation upon treatment with curcumin. When a super-repressor form of IkappaB-alpha (known to inhibit NF-kappaB) was transfected transiently into relA-transfected cells, the cells were no longer resistant to curcumin. Our results highlight a critical anti-apoptotic role for NF-kappaB in curcumin-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c000105200"xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/author | "Karunagaran D."xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/author | "Anto R.J."xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/author | "Maliekal T.T."xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/pages | "15601-15604"xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/title | "L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10747850 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10747850 |
| http://purl.uniprot.org/citations/10747850 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10747850 |
| http://purl.uniprot.org/uniprot/P25963#attribution-9BD841D64324C3EBDA0969EA92BD8029 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10747850 |
| http://purl.uniprot.org/uniprot/Q04206#attribution-869367CB05D760766874A891ED363B34 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10747850 |