| http://purl.uniprot.org/citations/10747952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10747952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10747952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/10747952 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular genetic basis of the P histo-blood group system has eluded characterization despite extensive studies of the biosynthesis of the P(1), P, and P(k) glycolipids. The main controversy has been whether a single or two distinct UDP-Gal:Galbeta1-R 4-alpha-galactosyltransferases catalyze the syntheses of the structurally related P(1) and P(k) antigens. The P(1) polymorphism is linked to 22q11.3-ter. Data base searches with the coding region of an alpha4GlcNAc-transferase identified a novel homologous gene at 22q13.2 designated alpha4Gal-T1. Expression of full coding constructs of alpha4Gal-T1 in insect cells revealed it encoded P(k) but not P(1) synthase activity. Northern analysis showed expression of the transcript correlating with P(k) synthase activity and antigen expression in human B cell lines. Transfection of P(k)-negative Namalwa cells with alpha4Gal-T1 resulted in strong P(k) expression. A single homozygous missense mutation, M183K, was found in six Swedish individuals of the rare p phenotype, confirming that alpha4Gal-T1 represented the P(k) gene. Sequence analysis of the coding region of alpha4Gal-T1 in P(1)+/-individuals did not reveal polymorphisms correlating with P(1)P(2) typing."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000728200"xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000728200"xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M000728200"xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Bennett E.P."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Bennett E.P."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Carlier K."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Carlier K."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Cedergren B."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Cedergren B."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Clausen H."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Clausen H."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Jersild C."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Jersild C."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Levery S.B."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Levery S.B."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Nilsson Sojka B."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Nilsson Sojka B."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Steffensen R."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Steffensen R."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Stroud M."xsd:string |
| http://purl.uniprot.org/citations/10747952 | http://purl.uniprot.org/core/author | "Stroud M."xsd:string |