| http://purl.uniprot.org/citations/10748056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10748056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10748056 | http://www.w3.org/2000/01/rdf-schema#comment | "Potassium leak conductances were recently revealed to exist as independent molecular entities. Here, the genomic structure, cardiac localization, and biophysical properties of a murine example are considered. Kcnk3 subunits have two pore-forming P domains and unique functional attributes. At steady state, Kcnk3 channels behave like open, potassium-selective, transmembrane holes that are inhibited by physiological levels of proton. With voltage steps, Kcnk3 channels open and close in two phases, one appears to be immediate and one is time-dependent (tau = approximately 5 ms). Both proton block and gating are potassium-sensitive; this produces an anomalous increase in outward flux as external potassium levels rise because of decreased proton block. Single Kcnk3 channels open across the physiological voltage range; hence they are "leak" conductances; however, they open only briefly and rarely even after exposure to agents that activate other potassium channels."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m001948200"xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m001948200"xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Goldstein S.A.N."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Goldstein S.A.N."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Butler M.H."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Butler M.H."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Gallagher P.G."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Gallagher P.G."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Buck M.E."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Buck M.E."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Lopes C.M.B."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/author | "Lopes C.M.B."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/pages | "16969-16978"xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/pages | "16969-16978"xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/title | "Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/title | "Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3."xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10748056 | http://purl.uniprot.org/core/volume | "275"xsd:string |