| http://purl.uniprot.org/citations/10748240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10748240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10748240 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling through its widely distributed cell surface receptor, interleukin (IL)-17 enhances the transcription of genes encoding proinflammatory molecules. Although it has been well documented that IL-17 activates the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase (JNK), the upstream signaling events are largely unknown. Here we report the requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in IL-17-induced NF-kappaB and JNK activation. In embryonic fibroblasts (EFs) derived from TRAF6 knockout mice, IL-17 failed to activate the IkappaB kinases (IKKs) and JNK. Consequently, IL-17-induced IL-6 and intercellular adhesion molecule 1 expression in the TRAF6-deficient cells was abolished. Lack of TRAF6 appeared to be the sole defect responsible for the observed failure to respond to IL-17, because transient transfection of TRAF6 expression plasmid into the TRAF6-deficient cells restored IL-17-induced NF-kappaB activation in a luciferase reporter assay. Furthermore, the levels of IL-17 receptor (IL-17R) on the TRAF6-deficient EFs were comparable to those on the wild-type control cells. Defect in IL-17 response was not observed in TRAF2-deficient EFs. Moreover, when TRAF6 and IL-17R were coexpressed in 293 cells, TRAF6 coimmunoprecipitated with IL-17R. Together, these results indicate that TRAF6, but not TRAF2, is a crucial component in the IL-17 signaling pathway leading to proinflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.191.7.1233"xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.191.7.1233"xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/author | "Cao Z."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/author | "Yamaguchi K."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/author | "Yamaguchi K."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/author | "Schwandner R."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/author | "Schwandner R."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/pages | "1233-1240"xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/pages | "1233-1240"xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/title | "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/title | "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction."xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/10748240 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10748240 |
| http://purl.uniprot.org/citations/10748240 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10748240 |
| http://purl.uniprot.org/citations/10748240 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10748240 |
| http://purl.uniprot.org/citations/10748240 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10748240 |