| http://purl.uniprot.org/citations/10749887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10749887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10749887 | http://www.w3.org/2000/01/rdf-schema#comment | "As part of a large scale effort to discover novel secreted proteins, a cDNA encoding a novel cytokine was identified. Alignments of the sequence of the new protein, designated IL-17B, suggest it to be a homolog of the recently described T cell-derived cytokine, IL-17. By Northern analysis, EST distribution and real-time quantitative polymerase chain reaction analysis, mRNA was detected in many cell types. A novel type I transmembrane protein, identified in an EST data base by homology to IL-17R, was found to bind specifically IL-17B, as determined by surface plasmon resonance analysis, flow cytometry, and co-immunoprecipitation experiments. Readily detectable transcription of IL-17BR was restricted to human kidney, pancreas, liver, brain, and intestines and only a few of the many cell lines tested. By using a rodent ortholog of IL-17BR as a probe, IL-17BR message was found to be drastically up-regulated during intestinal inflammation elicited by indomethacin treatment in rats. In addition, intraperitoneal injection of IL-17B purified from Chinese hamster ovary cells caused marked neutrophil migration in normal mice, in a specific and dose-dependent manner. Together these results suggest that IL-17B may be a novel proinflammatory cytokine acting on a restricted set of target cell types. They also demonstrate the strength of genomic approaches in the unraveling of novel biological pathways."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m910228199"xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m910228199"xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Olsen H."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Olsen H."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Fisher C.L."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Fisher C.L."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Barber M.C."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Barber M.C."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Ebner R."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Ebner R."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Cho Y.H."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Cho Y.H."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Wilkinson K.A."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Wilkinson K.A."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Ruben S.M."xsd:string |
| http://purl.uniprot.org/citations/10749887 | http://purl.uniprot.org/core/author | "Ruben S.M."xsd:string |