| http://purl.uniprot.org/citations/10749889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10749889 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogen and insulin-like-growth factor 1 (IGF-1) are potent mitogenic stimuli that share important properties in the control of cellular proliferation. However, the coupling between the signaling cascades of estrogen receptors alpha and beta and the IGF-1 receptor (IGF-1R) is poorly understood. Therefore, we selectively transfected estrogen receptor alpha or beta in COS7 and HEK293 cells, which contain IGF-1R. In presence of estrogen receptor alpha but not beta, 17beta-estradiol (E2) rapidly induces phosphorylation of the IGF-1R and the extracellular signal-regulated kinases 1/2. Furthermore, upon stimulation with E2, estrogen receptor alpha but not beta bound rapidly to the IGF-1R in COS7 as well as L6 cells, which express all investigated receptors endogenously. Control experiments in the IGF-1R-deficient fibroblast cell line R(-) showed that after stimulation with E2 only estrogen receptor alpha bound to the transfected IGF-1R. Overexpression of dominant negative mitogen-activated protein kinases kinase inhibited this effect. Finally, estrogen receptor alpha but not beta is required to induce the activation of the estrogen receptor-responsive reporter ERE-LUC in IGF-1-stimulated cells. Taken together, these data demonstrate that ligand bound estrogen receptor alpha is required for rapid activation of the IGF-1R signaling cascade."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m910345199"xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/author | "Meyer R."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/author | "Vetter H."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/author | "Grohe C."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/author | "Kahlert S."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/author | "Nuedling S."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/author | "van Eickels M."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/pages | "18447-18453"xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/title | "Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway."xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10749889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10749889 |
| http://purl.uniprot.org/citations/10749889 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10749889 |
| http://purl.uniprot.org/uniprot/Q92731#attribution-8C8DDC5CBB562A9A57D615DBE7973A68 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10749889 |
| http://purl.uniprot.org/uniprot/P03372#attribution-8C8DDC5CBB562A9A57D615DBE7973A68 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10749889 |
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| http://purl.uniprot.org/uniprot/#_P29353-mappedCitation-10749889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10749889 |
| http://purl.uniprot.org/uniprot/P03372 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10749889 |
| http://purl.uniprot.org/uniprot/P29353 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10749889 |
| http://purl.uniprot.org/uniprot/P08069 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10749889 |