| http://purl.uniprot.org/citations/10753883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10753883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10753883 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a cDNA encoding a novel inositol polyphosphate 5-phosphatase. It contains two highly conserved catalytic motifs for 5-phosphatase, has a molecular mass of 51 kDa, and is ubiquitously expressed and especially abundant in skeletal muscle, heart, and kidney. We designated this 5-phosphatase as SKIP (Skeletal muscle and Kidney enriched Inositol Phosphatase). SKIP is a simple 5-phosphatase with no other motifs. Baculovirus-expressed recombinant SKIP protein exhibited 5-phosphatase activities toward inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol (PtdIns) 4,5-bisphosphate, and PtdIns 3,4, 5-trisphosphate but has 6-fold more substrate specificity for PtdIns 4,5-bisphosphate (K(m) = 180 microM) than for inositol 1,4, 5-trisphosphate (K(m) = 1.15 mM). The ectopic expression of SKIP protein in COS-7 cells and immunostaining of neuroblastoma N1E-115 cells revealed that SKIP is expressed in cytosol and that loss of actin stress fibers occurs where the SKIP protein is concentrated. These results imply that SKIP plays a negative role in regulating the actin cytoskeleton through hydrolyzing PtdIns 4,5-bisphosphate."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.15.10870"xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.275.15.10870"xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Mochizuki Y."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Mochizuki Y."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Asano T."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Asano T."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Ijuin T."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Ijuin T."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Funaki M."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/author | "Funaki M."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/pages | "10870-10875"xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/pages | "10870-10875"xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/title | "Identification and characterization of a novel inositol polyphosphate 5-phosphatase."xsd:string |
| http://purl.uniprot.org/citations/10753883 | http://purl.uniprot.org/core/title | "Identification and characterization of a novel inositol polyphosphate 5-phosphatase."xsd:string |