| http://purl.uniprot.org/citations/10754285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10754285 | http://www.w3.org/2000/01/rdf-schema#comment | "To test whether accumulation of naive lymphocytes is sufficient to trigger lymphoid development, we generated mice with islet expression of the chemokine TCA4/SLC. This chemokine is specific for naive lymphocytes and mature dendritic cells (DC) which express the CCR7 receptor. Islets initially developed accumulations of T cells with DC, with scattered B cells at the perimeter. These infiltrates consolidated into organized lymphoid tissue, with high endothelial venules and stromal reticulum. Infiltrate lymphocytes showed a naive CD44low CD25- CD69-phenotype, though half were CD62L negative. When backcrossed to RAG-1 knockout, DC were not recruited. Interestingly, islet lymphoid tissue developed in backcrosses to Ikaros knockout mice despite the absence of normal peripheral nodes. Our results indicate that TCA4/SLC can induce the development and organization of lymphoid tissue through diffential recruitment of T and B lymphocytes and secondary effects on stromal cell development."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.8.3955"xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/author | "Dorf M.E."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/author | "Lo D."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/author | "Reilly C.R."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/pages | "3955-3959"xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/title | "Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis."xsd:string |
| http://purl.uniprot.org/citations/10754285 | http://purl.uniprot.org/core/volume | "164"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A8Q0LUK7-mappedCitation-10754285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10754285 |
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