| http://purl.uniprot.org/citations/10761935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10761935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10761935 | http://www.w3.org/2000/01/rdf-schema#comment | "Bitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying paper, we report the characterization of a large family of putative mammalian taste receptors (T2Rs). Here we use a heterologous expression system to show that specific T2Rs function as bitter taste receptors. A mouse T2R (mT2R-5) responds to the bitter tastant cycloheximide, and a human and a mouse receptor (hT2R-4 and mT2R-8) responded to denatonium and 6-n-propyl-2-thiouracil. Mice strains deficient in their ability to detect cycloheximide have amino acid substitutions in the mT2R-5 gene; these changes render the receptor significantly less responsive to cycloheximide. We also expressed mT2R-5 in insect cells and demonstrate specific tastant-dependent activation of gustducin, a G protein implicated in bitter signaling. Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80706-0"xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80706-0"xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Adler E."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Adler E."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Hoon M.A."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Hoon M.A."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Zuker C.S."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Zuker C.S."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Mueller K.L."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Mueller K.L."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Ryba N.J.P."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Ryba N.J.P."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Chandrashekar J."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/author | "Chandrashekar J."xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10761935 | http://purl.uniprot.org/core/name | "Cell"xsd:string |