| http://purl.uniprot.org/citations/10764216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10764216 | http://www.w3.org/2000/01/rdf-schema#comment | "Our study aimed to assess the roles of nitric oxide derived from endothelium NO-synthase (eNOS) and macula densa neuronal NO-synthase (nNOS) in the regulation of renal renin expression. For this purpose renin mRNA levels and renin content were determined in kidneys of wild-type (wt), nNOS-deficient (nNOS-/-), and eNOS-deficient (eNOS-/-) mice, in which the renin system was suppressed by feeding a high-salt diet (NaCl 4%), or was stimulated by feeding a low-salt (NaCl 0.02%) diet together with the converting-enzyme inhibitor ramipril (10 mg kg(-1) day(-1)). In all mouse strains, renin mRNA levels were inversely related to the rate of sodium intake. In eNOS-/-mice renin mRNA levels and renal renin content were 50% lower than in wt mice at each level of salt intake, whilst in nNOS-/-mice renin expression was not different from wt controls. Administration of the general NO-synthase inhibitor nitro-L-arginine methyl ester (L-NAME, 50 mg kg(-1) day(-1)) to mice kept on the low-salt/ramipril regimen caused a decrease of renal renin mRNA levels in wt and nNOS-/- mice, but not in eNOS-/-mice. These observations suggest that neither eNOS nor nNOS is essential for up- or downregulation of renin expression. eNOS-derived NO appears to enhance renin expression, whereas nNOS-derived NO does not."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.org/dc/terms/identifier | "doi:10.1007/s004249900214"xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/author | "Wagner C."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/author | "Schrader J."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/author | "Kurtz A."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/author | "Schnermann J."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/author | "Ford M."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/author | "Godecke A."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/name | "Pflugers Arch"xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/pages | "567-572"xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/title | "Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/10764216 | http://purl.uniprot.org/core/volume | "439"xsd:string |
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